Season 4 of Big Mouth focuses on anxiety; the anxiety of growing up, of figuring out who you are, discovering yourself, accepting yourself. The season starts at summer camp before our gang heads to 8th grade. Maria Bamford descends as Tito the Mosquito, the anxiety-ridden insect who targets all our favorite kids. As the season progresses, we meet Zach Galifianakis’ Gratitoad, who is there to help our crew cope with their anxiety and not let it completely own them. In the great Big Mouth tradition, the show continues to explore human sexuality and everything around it, including racial and sexual identity, love in all its forms, and having “The Hugest Period Ever.”

Check out the trailer below!

Additional guest stars include Seth Rogen, Josie Totah, Lena Waithe, Quinta Brunson, John Oliver, Sterling K. Brown, Paul Giamatti, Maya Erskine and Anna Konkle. As previously announced, Ayo Edebiri has been cast as Missy and will first be introduced during the penultimate episode as her character continues to evolve. She will continue to voice Missy in the final episode and for future seasons.

BIG MOUTH (L to R) Nick Kroll as Nick Birch, John Mulaney as Andrew Glouberman and Seth Rogan as Seth in episode 1 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH Jessi Klein as Jessi Glaser and Maria Bamford as Tito in episode 7 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH (L to R) Nick Kroll as Maury the Hormone Monster, Andrew Rannells as Matthew MacDell and Zachary Quinto as Aiden in episode 1 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH (L to R) Jessi Klein as Jessi Glaser, Zach Galifianakis as Gratitoad and Maya Rudolph as Connie the Hormone Monstress in episode 10 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH (L to R) Nick Kroll as Nick Birch and Maria Bamford as Tito in episode 3 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH (L to R) Maya Rudolph as Connie the Hormone Monstress and Nick Kroll as Maury the Hormone Monster in episode 1 of BIG MOUTH. Cr. NETFLIX © 2020

BIG MOUTH (L to R) Alia Shawkat as Roland, Maya Rudolph as Avery, Jak Knight as Del, John Oliver as Harry, Paul Scheer as Schwartz, Mitra Jouhari as Bahar, Maria Bamford as October, and Emily Altman as Milk in episode 1 of BIG MOUTH. Cr. NETFLIX © 2020